This NRA jointly solicits ground-based, bed rest definition and flight definition proposals for the NASA Human Research Program (HRP) and the National Space Biomedical Research Institute (NSBRI). Proposals are solicited by the HRP in the areas of Bone, Cardiovascular, Muscle, Nutrition, and Lunar Analog Bed Rest Investigations. Proposals are solicited by the NSBRI in the areas of Bone Loss; Cardiovascular Alterations; Human Performance Factors, Sleep and Chronobiology; Muscle Alterations and Atrophy; Neurobehavioral and Psychosocial Factors; Nutrition, Physical Fitness and Rehabilitation; Sensorimotor Adaptation; Smart Medical Systems; and Technology Development. Proposals responding to the HRP emphases and NSBRI emphases must be submitted separately, and will result in separate evaluations and awards. Step-1 proposals are due on September 14, 2007, and invited Step-2 proposals are due on December 14, 2007.

Participation is open to all categories of organizations, including educational institutions, industry, nonprofit organizations, NASA centers, and other Government agencies. Electronic proposals to HRP may be submitted via the NASA Proposal data system NSPIRES (http://nspires.nasaprs.com/) or via Grants.gov. (http://www.grants.gov/). Electronic proposals to NSBRI must be submitted via NSPIRES. Proposals solicited through this NRA will use a two-step proposal process. Only Step-1 proposers determined to be relevant with respect to the solicited research of this NRA will be invited to submit full Step-2 proposals. Proposals must be submitted electronically.